Introduction
Protein-protein interactions are events in which physical contact occurs between two or more proteins that have specificity for each other. [1] Protein interaction networks diagram known protein-protein interactions. They are useful because they provide a broad overview of the various processes in which a protein of interest might participate.
Results
Discussion
This protein interaction network shows that NOG interacts with several proteins that are involved in osteogenesis. Interestingly, NOG itself is not shown to be directly involved in bone formation. However, it is known that noggin acts as a negative regulator of bone morphogenetic proteins (BMPs), which is the family of proteins that is involved in bone formation. Notably, NOG is directly involved in chondrogenesis, or cartilage formation. It is worth exploring whether this is the pathway by which NOG causes TCC.
References
[1]https://en.wikipedia.org/wiki/Protein%E2%80%93protein_interaction#:~:text=Protein%E2%80%93protein%20interactions%20(PPIs),bonding%20and%20the%20hydrophobic%20effect.
[2] https://string-db.org/cgi/network?taskId=bljwemyhOy2i&sessionId=bijct9cLDys1
[3] https://string-db.org/cgi/network?taskId=bWGH4K1P2fBi&sessionId=bijct9cLDys1
[2] https://string-db.org/cgi/network?taskId=bljwemyhOy2i&sessionId=bijct9cLDys1
[3] https://string-db.org/cgi/network?taskId=bWGH4K1P2fBi&sessionId=bijct9cLDys1