Introduction
Domains are distinct functional and/or structural units within a protein. [1] Often, domains have a specific purpose that contributes to the overall role of the protein. For example, transcription factors often have a DNA binding domain, which is responsible for binding the promoter of the gene regulated by that particular transcription factor. Gene products can have one or more domains. These domains are usually conserved between species. Understanding the function of the domains within a protein can shed light on the protein's larger purpose.
Results
Discussion
The NOG gene product has only one domain, called the noggin domain. It is well conserved in vertebrates and even has a paralog in some organisms. The noggin domain is responsible for the dimerization of noggin and the binding of bone morphogenetic proteins (BMPs) as a way to inhibit them.
References
[1] https://www.ebi.ac.uk/training/online/courses/protein-classification-intro-ebi-resources/protein-classification/what-are-protein-domains/